Recent advances in endoscopic devices have increased their use for minimal invasive diagnostic and intervention procedures.Among all endoscopic modalities, bronchoscopy is one of the most frequent with around 261 millions of procedures per year.Although the use of bronchoscopy is spread among clinical facilities it presents some drawbacks, being th

Natural biomaterials have been widely applied in wound treatment.Hotspots in this area are focused on reducing their immunogenicity and improving their therapeutic effect.In this work, we present a novel aquaculture derived hybrid skin patch based on acellular fish skin Western Saddle Synthetic (AFS) and chitosan (CS) for wound healing.Such functio

BackgroundPeople infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) experience a wide range of clinical manifestations, from asymptomatic and mild illness to severe illness and death, influenced by age and a variety of comorbidities.Neutralizing antibodies (nAbs) are thought to be a primary immune defense against the virus.L

Abstract Background The intracellular bacterium Listeria monocytogenes is an attractive vector for cancer immunotherapy as it can effectively deliver tumor antigens to antigen-presenting cells, leading to a robust antitumor response.Results In this study, we developed a novel vaccine platform called Listeria-based Live Attenuated Double Substitutio

Dynamical vectors characterizing instability and applicable as ensemble perturbations for prediction with geophysical fluid dynamical models are analysed.The relationships between covariant Lyapunov vectors (CLVs), orthonormal Lyapunov vectors (OLVs), singular vectors (SVs), Floquet vectors and finite-time normal modes (FTNMs) are examined for peri